DNA Damage Repair - Introduction

Introduction to DNA Damage Repair

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Introduction to DNA Damage Repair

DNA in cells can be damaged by both environmental factors (for example, UV light, high-energy radiation, or mutagenic industrial chemicals) and normal metabolic processes (for example, production of reactive oxygen species (ROS) or replication errors) (1). While some lesions result from single-stranded or double-stranded breaks in the DNA sugar-phosphate backbone, in most cases, the nucleotide bases have been modified chemically. If such a lesion occurs within a gene, the structural distortion could alter or eliminate the ability of the cell to transcribe or replicate the gene, or possibly lead to a potentially harmful mutation that would deleteriously affect the survival of the daughter cells after the parent cell undergoes mitosis (2). The cell has corresponding DNA repair mechanisms that enable it to respond to the various types of DNA damage described above, mechanisms such as DNA base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), or direct reversal (3-6). The DNA Damage Repair category encompasses those modifications that can be incorporated into oligonucleotides for use as research tools in investigational studies into the various biochemical processes involved in the damage and repair of DNA or RNA in the cell.

DNA Damage Repair Modifications						View PDF	Excel Mods & Code List
Product	Code	Catalog No.	50 nmol scale (XX=05)	200 nmol scale (XX=02)	1 mmol scale (XX=01)	2 mmol scale (XX=03)	10 mmol scale (XX=10)	15 mmol scale (XX=15)
5-hm dC (5-Hydroxymethyl-dC)	[5hm-dC]	26-6707	$594.00	$594.00	$659.00	$772.00	$3,568.00	$4,433.00
5-hydroxy dC	[5-OH-dC]	26-6701	$385.00	$385.00	$425.00	$525.00	$3,398.00	$4,247.00
5-hydroxy deoxyuridine (OH dU)	[5-OH-dU]	26-6695	$267.00	$267.00	$347.00	$521.00	$2,780.00	$3,475.00
8-Oxo deoxyguanosine (8-Oxo dG)	[8-Oxo-dG]	26-6434	$383.00	$383.00	$498.00	$748.00	$3,987.00	$4,984.00
Abasic Site (dSpacer abasic furan-THF)	[dABS]	26-6435	$119.00	$119.00	$155.00	$233.00	$1,241.00	$1,551.00
dihydro dT (5-6 DHT)	[5-6-DHT]	26-6890	$253.00	$253.00	$329.00	$493.00	$2,628.00	$3,285.00
dihydro dUracil (5-6 DHdU)	[5-6-DHdU]	26-6683	$253.00	$253.00	$329.00	$493.00	$2,628.00	$3,285.00
deoxyuridine dU	[dU]	26-6408	$27.00	$27.00	$59.00	$119.00	$475.00	$594.00
etheno dexoyadenosine dA	[Eth dA]	26-6506	$255.00	$255.00	$352.00	$632.00	$2,814.00	$3,518.00
N3-methyl-dC [m3dC]	[m3dC]	26-6903	$253.00	$253.00	$329.00	$493.00	$2,628.00	$3,285.00
N6-Methyl dA (m6dA)	[m6dA]	26-6601	$345.00	$345.00	$415.00	$535.00	$1,825.00	$2,282.00
O6 Methyl dG	[O6-Me-dG]	26-6409	$416.00	$416.00	$551.00	$416.00	$1,769.00	$2,211.00
rAbasic Site (rSpacer abasic furan)	[rABS]	26-6442	$194.00	$194.00	$253.00	$379.00	$2,022.00	$2,527.00
Thymidine Glycol	[Tg-Thy-Glycol]	26-6487	$465.00	$465.00	$543.00	$664.00	$3,542.00	$4,428.00
Cis-syn Thymine Dimer Cyclobutane Pyrimidine Dimer (CPD)	[Cis-TT]	26-6680	$2,786.00	$2,786.00	$3,964.00	$5,551.00	$20,045.00	$24,054.00

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DNA Damage Repair - Introduction

Introduction to DNA Damage Repair

DNA Damage Repair Modifications