Cellular Delivery - Introduction

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Introduction to Cellular Delivery

Oligonucleotides are single-stranded nucleic acid molecules, and due to their phosphodiester backbones, are predominantly hydrophilic. While this is usually not a problem for in vitro applications, for in vivo work, the hydrophobic nature of the cell membrane makes it difficult for oligos to permeate it and enter the cell. The need to modify oligos to improve their membrane permeability and cellular uptake can be critical in anti-sense, siRNA, or in vivo diagnostic applications. Generally speaking, such modifications need to be both hydrophobic and relatively non-toxic. Modification of oligos at the 5'- or 3'-ends with cholesterol or PEG are strategies commonly used to achieve this.

Cellular Delivery Modifications						View PDF	Excel Mods & Code List
Product	Code	Catalog No.	50 nmol scale (XX=05)	200 nmol scale (XX=02)	1 mmol scale (XX=01)	2 mmol scale (XX=03)	10 mmol scale (XX=10)	15 mmol scale (XX=15)
Alpha Tocopherol TEG (Vitamin E)	[a-toco-TEG]	26-6616	$319.00	$319.00	$405.00	$486.00	$1,075.00	$1,312.00
Alpha-linolyl (C18:3α) ALA LMO	[3-ALA-C18-3]	26-6784	$254.00	$286.00	$335.00	$394.00	$2,133.00	$2,500.00
Arachidonyl (C20:4) AA LMO	[3-AA-C20-4]	26-6787	$254.00	$286.00	$335.00	$394.00	$2,133.00	$2,500.00
butyric acid (C4) Modified Oligo	[3-BA-C4]	26-6782	$120.00	$120.00	$150.00	$225.00	$850.00	$1,200.00
Cholesterol TEG (15 atom triethylene glycol spacer) LMO	[CholTEG]	26-6602	$235.00	$235.00	$265.00	$325.00	$1,066.00	$1,361.00
Cholesterol TEG-3' (15 atom triethylene glycol spacer) LMO	[3-CholTEG]	26-6570	$189.00	$189.00	$227.00	$286.00	$1,066.00	$1,361.00
Delta Tocopherol TEG (Vitamin E)	[d-toco-TEG]	26-6628	$319.00	$319.00	$405.00	$486.00	$1,075.00	$1,312.00
Docosanoic (C22) DCA LMO	[3-DCA-C22]	26-6627	$254.00	$286.00	$335.00	$394.00	$2,133.00	$2,500.00
Docosahexaenoic (C22:6) DHA LMO	[3-DHA-C22-6]	26-6626	$254.00	$286.00	$335.00	$394.00	$2,133.00	$2,500.00
Dihomo-gamma-linolyl (C20:3) DGLA LMO	[3-DGLA-C20-3]	26-6786	$254.00	$286.00	$335.00	$394.00	$2,133.00	$2,500.00
Eicosapent (20:5) EPA LMO	[3-EPA-C20-5]	26-6788	$254.00	$286.00	$335.00	$394.00	$2,133.00	$2,500.00
GalNAc Oligo N-Acetylgalactosamine C3	[GalNAc]	26-6751	$416.00	$416.00	$443.00	$490.00	$1,388.00	$1,630.00
GalNAc Trivalent TEG	[GalNAc-TEG3X]	26-6735	$443.00	$443.00	$502.00	$583.00	$3,262.00	$4,018.00
Gamma-linolyl (C18:3γ) GLA LMO	[3-GLA-C18-3]	26-6785	$254.00	$286.00	$335.00	$394.00	$2,133.00	$2,500.00
Lignoceryl C24 (3') LMO	[3-Lig-C24]	26-6624	$513.00	$610.00	$848.00	$1,782.00	$4,914.00	$6,113.00
Lignoceryl C24 (5') LMO	[5-Lig-C24]	26-6625	$513.00	$610.00	$848.00	$1,109.00	$4,914.00	$6,113.00
Linolyl (C18:2) LA LMO	[3-LA-C18-2]	26-6783	$254.00	$286.00	$335.00	$394.00	$2,133.00	$2,500.00
Ethoxy Phosphate dA	[EoP-dA]	26-6641A	$90.00	$90.00	$116.00	$145.00	$680.00	$880.00
Ethoxy Phosphate dC	[EoP-dC]	26-6641C	$90.00	$90.00	$116.00	$145.00	$680.00	$880.00
Ethoxy Phosphate dG	[EoP-dG]	26-6641G	$90.00	$90.00	$116.00	$145.00	$680.00	$880.00
Ethoxy Phosphate dT	[EoP-dT]	26-6641T	$90.00	$90.00	$116.00	$145.00	$680.00	$880.00
Methoxy Phosphate dA	[MoP-dA]	26-6642A	$90.00	$90.00	$116.00	$145.00	$680.00	$880.00
Methoxy Phosphate dC	[MoP-dC]	26-6642C	$90.00	$90.00	$116.00	$145.00	$680.00	$880.00
Methoxy Phosphate dG	[MoP-dG]	26-6642G	$90.00	$90.00	$115.00	$145.00	$680.00	$880.00
Methoxy Phosphate dT	[MoP-dT]	26-6642T	$90.00	$90.00	$116.00	$145.00	$680.00	$880.00
Palmityl C16 (3') LMO	[3-Pal-C16]	26-6621	$513.00	$610.00	$848.00	$1,109.00	$4,914.00	$6,113.00
Palmityl C16 (5') LMO	[5-Pal-C16]	26-6622	$513.00	$610.00	$848.00	$1,109.00	$4,914.00	$6,113.00
Palmityl C16 Oligo (NHS) LMO	[Pal-C16-N]	26-6619	$513.00	$610.00	$1,042.00	$1,782.00	$4,914.00	$6,113.00
Propionyl (C3) PA LMO	[3-PA-C3]	26-6781	$120.00	$120.00	$150.00	$225.00	$850.00	$1,200.00
Puromycin	[Puro]	26-6603	$82.00	$82.00	$107.00	$160.00	$854.00	$1,067.00
Spacer 18 (hexaethyleneglycol)	[Sp18]	26-6447	$106.00	$106.00	$159.00	$200.00	$810.00	$945.00
Spermine Oligo Cationic Tail (ZNA-Oligos)	[Spm]	26-6454	$350.00	$350.00	$455.00	$682.00	$3,639.00	$4,549.00
Stearyl C18 LMO LMO 3'	[3-Str-C18]	26-6623	$200.00	$200.00	$255.00	$362.00	$1,782.00	$2,144.00
Stearyl C18 LMO Oligo 5'	[5-Str-C18]	26-6617	$81.00	$81.00	$119.00	$200.00	$556.00	$729.00

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Cellular Delivery - Introduction

Introduction to Cellular Delivery

Cellular Delivery Modifications